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Updated: Sep 28, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
The base composition of the genes is correlated with the secondary structures of the encoded proteins
Giuseppe D'Onofrio1, Tapash Chandra Ghosh, Giorgio Bernardi
1Laboratorio di Evoluzione Molecolare, Stazione Zoologica A. Dohrn, Naples, Italy. donofrio@sunev.szn.it
Abstract:
The analysis of a non-redundant set of human proteins, for which both the crystallographic structures and the corresponding gene sequences are available, show that bases at third codon position are non-uniformly distributed along the coding sequences. Significant compositional differences are found by comparing the gene regions corresponding to the different secondary structures of the proteins. Inter-and intra-structure differences were most pronounced in the GC-richest genes. These results are not compatible with any proposed hypotheses based on a neutral process of formation/maintenance of the high GC(3) levels of the genes localized in the GC-richest isochores of the human genome.
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