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Published on: March 14, 2019
Review article: Paediatric bone and joint infection
1Starship Children's Hospital, Auckland, New Zealand.
Abstract:
Paediatric musculoskeletal infection remains an important cause of morbidity. Methicillin sensitive Staphylococcus aureus is still the most common organism although the incidence of methicillin resistant S. aureus in the community is rising. Osteomyelitis and septic arthritis due to Haemophilus influenzae is decreasing in incidence secondary to immunisation and in some units has been replaced by infections with the gram negative bacillus, Kingella kingae. Recent prospective studies indicate that uncomplicated osteomyelitis can be treated by three to four weeks of antibiotics. However, there is still a small group of children who will have overwhelming disseminated infection. These children require aggressive surgical and medical intervention. Two recent reports have identified an increased incidence of septic arthritis in children who have hemophilia and are HIV positive.
Insights
Pediatric musculoskeletal infections are common, with Staphylococcus aureus being a frequent cause. While most osteomyelitis cases are treatable with antibiotics, severe infections require intensive care.
Area of Science:
- Pediatric infectious diseases
- Musculoskeletal infections in children
Background:
- Paediatric musculoskeletal infections cause significant morbidity.
- Methicillin-sensitive Staphylococcus aureus is the most common pathogen, but community-acquired methicillin-resistant Staphylococcus aureus is increasing.
- Haemophilus influenzae infections are decreasing due to immunization, with Kingella kingae becoming more prevalent.
Purpose of the Study:
- To review current trends and treatment strategies for pediatric musculoskeletal infections.
- To highlight changes in causative organisms and emerging risk factors.
Main Methods:
- Review of recent prospective studies and reports on pediatric musculoskeletal infections.
- Analysis of trends in causative organisms and treatment outcomes.
Main Results:
- Uncomplicated osteomyelitis can be effectively treated with 3-4 weeks of antibiotics.
- A subset of children experiences overwhelming disseminated infections requiring aggressive intervention.
- Increased septic arthritis incidence is noted in children with hemophilia and HIV positivity.
Conclusions:
- Treatment for pediatric musculoskeletal infections should be tailored to infection severity.
- Awareness of changing microbial patterns and specific patient populations (e.g., those with hemophilia and HIV) is crucial for effective management.
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