Helicobacter pylori-associated large gastric ulcer during treatment for childhood leukemia
Francesca Fioredda1, Riccardo Haupt, Elio Castagnola
1Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, G. Gaslini Children's Hospital, Largo Gerolamo Gaslini 5, 16148 Genoa, Italy. francescafioredda@ospedale-gaslini.it
Abstract:
During treatment of acute lymphoblastic leukemia, serious gastrointestinal complications rarely occur in children. Helicobacter pylori is not known as a pathogen causing peptic ulcer in children with leukemia who are receiving chemotherapy. We describe a 14-year-old girl with acute lymphoblastic leukemia in whom, during the most aggressive part of treatment, a large, life-threatening H. pylori-associated gastric ulcer developed. H. pylori infection played a role in the origin of the ulcer, as confirmed by the clinical resolution after its specific treatment. This case points to a possible role for H. pylori as a pathogen in children with leukemia who have either evident or occult gastrointestinal bleeding.
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