Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cholesteryl esters in human malignant neoplasms.

M R Tosi1, G Bottura, P Lucchi

  • 1Istituto di Citomorfologia Normale e Patologica del CNR, Bologna, Italy. raftosi@ciam.unibo.it

International Journal of Molecular Medicine
|December 7, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Secondhand Smoke from Conventional Cigarettes, IQOS, and E-Cigarettes on Children's Oral Health: A Cross-Sectional Study.

European journal of paediatric dentistry·2025
Same author

Nasal bone modification compared to normal growth after rapid maxillary expansion anchored onto deciduous teeth: a CBCT retrospective study.

European journal of paediatric dentistry·2024
Same author

Maternal mental health and children oral health: a literature review.

European journal of paediatric dentistry·2023
Same author

Rapid maxillary expansion for interceptive orthodontic treatment of palatally displaced canine: A systematic review.

European journal of paediatric dentistry·2021
Same author

Evaluation of tooth size in non-syndromic cleft lip and palate patients: A retrospective Italian study.

European journal of paediatric dentistry·2021
Same author

A Delphi consensus statement of the Neuropathic Pain Special Interest Group of the Italian Neurological Society on pharmacoresistant neuropathic pain.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2019

Cholesteryl esters (CholE) are elevated in high-grade malignant tumors like gliomas and renal cell carcinomas, but not in healthy tissues or benign growths. This suggests CholE may indicate cancer and guide new therapies.

Area of Science:

  • Oncology
  • Biochemistry
  • Medical Diagnostics

Background:

  • Cholesteryl esters (CholE) are lipids crucial for cellular function.
  • Their role in malignant neoplasms, particularly in relation to vascularization, remains under investigation.

Purpose of the Study:

  • To investigate the presence and levels of CholE in various human malignant neoplasms.
  • To explore the correlation between CholE levels and tumor vascularity and grade.
  • To assess CholE as potential biomarkers for cancer detection and therapeutic targets.

Main Methods:

  • In vitro nuclear magnetic resonance (NMR) spectroscopy was employed.
  • Analysis of total lipid extracts from human tumor tissues and healthy controls.
  • Comparison of CholE levels across different tumor types (gliomas, renal cell carcinomas) and grades.

Related Experiment Videos

Main Results:

  • CholE were detected in high-grade gliomas (glioblastomas, anaplastic oligodendrogliomas) and renal cell carcinomas.
  • Significantly higher CholE levels were observed in malignant tumors compared to healthy tissues and benign neoplasms.
  • CholE presence correlated with prominent neovascularity and vascular proliferation in tumors.
  • Renal cell carcinomas exhibited higher CholE levels than high-grade gliomas, with CholE mainly as oleate.

Conclusions:

  • Cholesteryl esters are significantly associated with malignant neoplasms, particularly those with high vascularity.
  • CholE may serve as a potential biochemical marker for cancer diagnosis and prognosis.
  • The findings suggest CholE as a potential target for novel cancer therapeutic strategies.