Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glucose-responsive insulin-producing cells from stem cells.

David J Kaczorowski1, Ethan S Patterson, William E Jastromb

  • 1Johns Hopkins University School of Medicine, Department of Gynecology and Obstetrics, Division of Developmental Genetics, Baltimore, Maryland, USA.

Diabetes/Metabolism Research and Reviews
|December 7, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum to 2025 American Association for Thoracic Surgery (AATS) Expert Consensus Document: Surgical management of acute myocardial infarction and associated complications: The Journal of Thoracic and Cardiovascular Surgery, Volume 170, Issue 5, 2025, Pages 1327-1344.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Long-term outcomes of postoperative atrial fibrillation after cardiac surgery: Results from 19,000 patients.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Conventional Cardiac Surgery in Donation After Circulatory Death Heart Transplantation: A United Network for Organ Sharing Registry Analysis.

Clinical transplantation·2026
Same author

Effects of Functional Warm Ischemia Time on Posttransplant Outcomes in Donation After Circulatory Death Heart Transplantation Using Direct Procurement and Perfusion.

Transplantation·2026
Same author

Impact of Circulatory Arrest Duration on Perioperative Mortality: Insights From More Than 1200 Aortic Arch Reconstructions.

The Annals of thoracic surgery·2026
Same author

Frozen Elephant Trunk for Retrograde Type A Aortic Dissection Within 1 Year Following Heart Transplant.

JACC. Case reports·2026
Same journal

Retinol, Carotenoid, and Tocopherol Intake and Status, and the Risk of Islet Autoimmunity and Type 1 Diabetes: The Environmental Determinants of Diabetes in the Young Study.

Diabetes/metabolism research and reviews·2026
Same journal

Glucokinase Regulatory Protein Gene Polymorphism as a Predictive Biomarker for Early Renal Injury in Newly Diagnosed Early-Onset Type 2 Diabetes Mellitus.

Diabetes/metabolism research and reviews·2026
Same journal

Hearing Loss in Adults With Diabetes and Prediabetes: A Systematic Review and Meta-Analysis.

Diabetes/metabolism research and reviews·2026
Same journal

The Effects of Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Co-Transporter-2 Inhibitors on Lean Body Mass in Humans: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Diabetes/metabolism research and reviews·2026
Same journal

Associations of GA and GMI/GA Ratio With All-Cause Mortality in Well-Controlled Type 2 Diabetes Defined by Continuous Glucose Monitoring.

Diabetes/metabolism research and reviews·2026
Same journal

Diabetic Foot Ulceration in Dialysis-Dependent End-Stage Kidney Disease: A Systematic Review of Epidemiology, Clinical Outcomes and Mortality Risk.

Diabetes/metabolism research and reviews·2026
See all related articles

Stem cells offer a promising path for type 1 diabetes treatment. Research into glucose-responsive insulin-producing (GRIP) cells derived from various stem cell sources could lead to widely available transplantation therapies.

Area of Science:

  • Regenerative Medicine
  • Endocrinology
  • Cell Biology

Background:

  • Type 1 diabetes requires cells that can both monitor blood glucose and produce insulin.
  • Successful islet cell transplantation with immunosuppression offers a potential treatment avenue.
  • Stem cells' ability to differentiate into specialized cells is key to developing new therapies.

Purpose of the Study:

  • To explore the potential of stem cells for generating glucose-responsive insulin-producing (GRIP) cells.
  • To identify stem cell sources capable of producing functional GRIP cells for type 1 diabetes treatment.
  • To assess the feasibility of stem cell transplantation as a widely available therapy for type 1 diabetes.

Main Methods:

  • Investigating the proliferative and differentiation capabilities of human embryonic stem (ES) cells and embryonic germ (EG) cells.

Related Experiment Videos

  • Examining endogenous stem cell sources for their potential to yield GRIP cells.
  • Reviewing existing research on stem cell differentiation into insulin-producing cells.

    • Main Results:

    • Human ES and EG cells show promise due to their differentiation capacity and proliferation.
    • Mouse ES cells have demonstrated the ability to normalize glucose levels in diabetic mice.
    • GRIP cells have been successfully derived from both embryonic and adult endogenous stem cell sources.

    Conclusions:

    • Stem cells hold significant promise for developing a transplantation-based treatment for type 1 diabetes.
    • The identification and derivation of GRIP cells from various stem cell sources are crucial for therapeutic advancement.
    • Stem cell-derived GRIP cells could provide a widely accessible treatment option for type 1 diabetes.