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Updated: Aug 14, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
[Clinico-immunologic subtypes of type I diabetes mellitus]
Aim:
To study clinico-immunological characteristics of diabetes mellitus type I.
Material And Methods:
Clinical examination was made of 333 patients with diabetes mellitus type I with manifestation of carbohydrate metabolism impairment and intoxication syndrome because of diabetic ketoacidosis (group 1) and without it (group 2). Compared to donors (n = 68), T-cell, B-cell and monocytic components of immune system were studied in patients with uncomplicated DM type 1 in both groups (28 and 15 patients, respectively).
Results:
Patients with different subtypes of the disease differ by the course and rate of progression, defects in T-cell and monocyte components of immunity.
Conclusion:
Type 1 diabetes mellitus is a heterogenous pathology with subtype 1 (rapidly progressive) and subtype 2 (slowly progressive).
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