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Related Experiment Videos

Nitrogen balance and calorie efficiency in small-for-date dwarfism.

I Krieger, C F Whitten

    The American Journal of Clinical Nutrition
    |January 1, 1976
    PubMed
    Summary

    Accelerated weight gain in infants, including those with dwarfing syndromes, showed higher calorie costs but appropriate nitrogen retention. Good nitrogen retention does not guarantee linear growth potential in infants.

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    Area of Science:

    • Pediatric Nutrition
    • Growth and Development
    • Metabolic Studies

    Background:

    • Infants small for their gestational age often exhibit growth failure.
    • Dwarfing syndromes can impact infant growth trajectories.
    • Understanding metabolic responses to weight gain is crucial for pediatric care.

    Purpose of the Study:

    • To evaluate the calorie cost of accelerated weight gain in small-for-date infants.
    • To assess nitrogen retention during rapid weight gain in this cohort.
    • To determine if nitrogen retention predicts linear growth potential.

    Main Methods:

    • Induction of accelerated weight gain in eight small-for-date infants, including two with dwarfing syndromes.
    • Comparison with control infants experiencing linear growth failure due to undernutrition.
    • Measurement of calorie cost and nitrogen retention during weight gain.

    Main Results:

    • The calorie cost of weight gain was higher in the study group than controls.
    • The inefficiency in calorie utilization was not practically significant.
    • Nitrogen retentions were appropriate for weight gain, or even better.
    • Elevated nitrogen retentions were observed in infants with small-for-date dwarfism and controls with low calorie intake.

    Conclusions:

    • Accelerated weight gain is achievable in small-for-date infants, with manageable metabolic costs.
    • Nitrogen retention alone is not a reliable indicator of future linear growth potential.
    • Further research is needed to identify predictors of linear growth in infants with growth failure.

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