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Updated: Aug 19, 2026
Colon Ascendens Stent Peritonitis (CASP) - a Standardized Model for Polymicrobial Abdominal Sepsis
Published on: December 19, 2010
Predictive factors of mortality due to polymicrobial peritonitis with Candida isolation in peritoneal fluid in
Hervé Dupont1, Catherine Paugam-Burtz, Claudette Muller-Serieys
1Department of Anesthesiology and Surgical Intensive Care Unit, University Hospital Bichat-Claude Bernard, Paris, France. herve.dupont@bch.ap-hop-paris.fr
Background:
Candida peritonitis (CP) is generally considered to be a severe disease, but its impact on outcome in critically ill patients remains unknown.
Hypothesis:
The predictive factors of mortality due to CP can be determined by study of a population of patients with CP.
Design:
A retrospective review of a prospective surgical intensive care unit (ICU) database of patients (January 1, 1994, through December 31, 2000).
Setting:
University hospital in Paris, France.
Patients:
Eighty-three patients with generalized CP.
Main Outcome Measures:
Demographic and microbiologic data and outcome were collected, and nonsurvivors were compared with survivors.
Results:
Overall ICU mortality due to CP was 43 (52%) of 83 patients. In a stepwise multivariate logistic regression, the following 4 variables were independently associated with mortality: APACHE II (Acute Physiology and Chronic Health Evaluation II) score on admission of at least 17 (odds ratio [OR], 28.4; 95% confidence interval [CI], 5.7-142.5; P<.001), respiratory failure on admission (OR, 10.6; 95% CI, 2.2-51.2; P =.003), upper gastrointestinal tract site of peritonitis (OR, 7.7; 95% CI, 1.7-34.7; P =.007), and results of direct examination of peritoneal fluid that were positive for Candida (OR, 4.7; 95% CI, 1.2-19.7; P =.002).
Conclusions:
These results confirm the severity of CP in ICU patients and emphasize the prognostic value of direct examination of peritoneal fluid for Candida in this context.
