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In vivo toxicity screening programs using metabonomics.

Lora C Robosky1, Donald G Robertson, J David Baker

  • 1Department of Discovery Technologies, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA.

Combinatorial Chemistry & High Throughput Screening
|December 10, 2002
PubMed
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Metabonomics, using nuclear magnetic resonance (NMR), rapidly screens animal health for toxicity and drug efficacy. This "omics" technology aids early drug discovery by assessing metabolic status, reducing costs and late-stage failures.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Analytical Chemistry

Background:

  • Metabonomics is an emerging technology for in vivo screening.
  • It assesses toxicity, disease state, and drug efficacy.
  • It complements genomics and proteomics by profiling small molecules.

Purpose of the Study:

  • To review the implementation of metabonomics screening programs.
  • To highlight its application from study design to data analysis.
  • To demonstrate its potential impact on early drug discovery.

Main Methods:

  • Utilizes high-resolution nuclear magnetic resonance (NMR) techniques.
  • Employs statistical data analysis methods.
  • Provides a metabolic fingerprint of biofluids over time.

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Main Results:

  • Metabonomics enables rapid evaluation of an animal's metabolic status.
  • It generates a unique metabolic fingerprint for each study.
  • Published results show its utility in drug discovery.

Conclusions:

  • Metabonomics facilitates early incorporation of safety endpoints in drug discovery.
  • This reduces the likelihood and cost of late-stage attrition.
  • It is a valuable tool for efficient and cost-effective drug development.