Related Experiment Video

Updated: Sep 28, 2026

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
08:57

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease

Published on: May 22, 2026

Influence of left ventricular geometry on regional systolic and diastolic function in patients with essential

Bahattin Balci1, Ozcan Yilmaz

  • 1Department of Cardiology, Ondokuz Mayis University, Samsun, Turkey. bahattinbalci@ttnet.net.tr

Scandinavian Cardiovascular Journal : SCJ
|December 10, 2002
PubMed

Insights

Left ventricular diastolic function is impaired in concentric hypertrophy among hypertensive patients. However, regional systolic function remains unaffected by left ventricular geometric patterns.

Area of Science:

  • Cardiology
  • Echocardiography
  • Hypertension Research

Background:

  • Essential hypertension often leads to left ventricular (LV) hypertrophy.
  • Global diastolic function is known to be impaired in concentric hypertrophy.
  • The impact of LV geometric patterns on regional systolic and diastolic function is not well understood.

Purpose of the Study:

  • To investigate how left ventricular geometric patterns influence regional systolic and diastolic function in hypertensive individuals.
  • To compare regional cardiac function across different LV geometric patterns.

Main Methods:

  • Studied 90 untreated patients with mild to moderate essential hypertension.
  • Utilized M-mode, standard Doppler, and tissue Doppler echocardiography.
  • Classified patients into four groups: normal geometry, concentric remodeling, eccentric hypertrophy, and concentric hypertrophy based on LV mass index and relative wall thickness.

Main Results:

  • Concentric hypertrophy group showed significantly lower E/A ratios compared to normal geometry.
  • Impaired diastolic function (lower Em velocity and Em/Am ratio) was observed in basal septum and inferior regions in the concentric hypertrophy group.
  • The number of segments with diastolic dysfunction was higher in concentric hypertrophy compared to normal geometry.
  • No significant differences in LV ejection fraction or regional S velocity were found among the groups.

Conclusions:

  • Left ventricular regional diastolic function is compromised in concentric hypertrophy.
  • Left ventricular geometric patterns do not appear to influence regional systolic function in hypertensive patients.
Abstract

More Related Videos

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats08:09

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension07:38

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...