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Updated: Sep 28, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Severe scleritis and urticarial lesions
Jennifer E Thorne1, Maria I Hernandez, Adrienne Rencic
1Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. jthorne@jhmi.edu
Purpose:
To report the first known case of bilateral scleritis in a patient with hypocomplementemic urticarial vasculitis.
Design:
Interventional case report.
Methods:
Medical and ophthalmic history, results of physical and ophthalmic examinations, laboratory data, and histologic and immunopathologic examination were reviewed and results recorded.
Results:
A 67-year-old man who presented with eye redness and pain, rash, arthralgia, and malaise was found to have hypocomplementemic urticarial vasculitis. Treatment with high-dose oral corticosteroids and mycophenolate mofetil resulted in the resolution of the rash and scleritis.
Conclusions:
Ocular involvement may be a helpful clue in the diagnosis of this uncommon syndrome.
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