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Related Experiment Videos

Butorphanol dependence and withdrawal decrease hippocampal kappa 2-opioid receptor binding.

Lir-Wan Fan1, Sachiko Tanaka, Younjoo Park

  • 1Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.

Brain Research
|December 10, 2002
PubMed
Summary
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Chronic butorphanol infusion alters kappa-opioid receptor expression in rat brains. Both kappa(1) and kappa(2) receptors increased in several regions, but showed distinct changes in the hippocampus during dependence and withdrawal.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Receptor Binding Assays

Background:

  • Opioid analgesics, like butorphanol, interact with kappa-opioid receptors.
  • Chronic use can lead to dependence and withdrawal, involving complex neuroadaptations.
  • Understanding receptor subtype changes is crucial for managing opioid effects.

Purpose of the Study:

  • To investigate the regional distribution and extent of kappa-opioid receptor subtype alterations.
  • To examine these changes during both butorphanol-induced dependence and withdrawal.
  • To elucidate the role of kappa(1) and kappa(2) receptors in the hippocampus during chronic opioid exposure.

Main Methods:

  • Chronic intracerebroventricular (i.c.v.) infusion of butorphanol in rats.
  • Autoradiography to characterize binding of kappa(1), kappa(2), and total kappa-opioid receptors.

Related Experiment Videos

  • Assessment during induced butorphanol dependence and subsequent withdrawal phases.

    • Main Results:

    • Significant increases in kappa(1) and kappa(2) opioid receptor binding were observed in multiple brain regions, including the frontal cortex and nucleus accumbens.
    • The hippocampus showed a unique pattern: decreased kappa(2) and increased kappa(1) receptor binding.
    • These alterations were present during both the dependence and withdrawal stages.

    Conclusions:

    • Chronic butorphanol exposure induces region-specific changes in kappa-opioid receptor subtypes.
    • The distinct hippocampal alterations suggest differential involvement of kappa(1) and kappa(2) receptors in adaptation and recovery from opioid exposure.
    • Findings highlight the complex neurobiological adaptations underlying opioid dependence and withdrawal.