Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperpolarization-activated cation currents: from molecules to physiological function.

Richard B Robinson1, Steven A Siegelbaum

  • 1Department of Pharmacology, Center for Molecular Therapeutics, Columbia University, New York, NY 10032, USA. rbr1@columbia.edu

Annual Review of Physiology
|December 10, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chemogenetic activation of hippocampal area CA2 promotes acute and chronic seizures in a mouse model of epilepsy.

bioRxiv : the preprint server for biology·2026
Same author

Chemogenetic activation of hippocampal area CA2 promotes acute and chronic seizures in a mouse model of epilepsy.

Neurobiology of disease·2026
Same author

Modulation of aggression by social novelty recognition memory in the hippocampal CA2 region.

Cell reports·2025
Same author

The ventral CA2 region of the hippocampus and its differential contributions to social memory and social aggression.

Cell reports·2025
Same author

The hippocampal CA2 region discriminates social threat from social safety.

Nature neuroscience·2024
Same author

HCN1 hyperpolarization-activated cyclic nucleotide-gated channels enhance evoked GABA release from parvalbumin-positive interneurons.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same journal

CaMKII in the Heart: From Homeostasis to Pathology.

Annual review of physiology·2026
Same journal

Cerebrospinal Fluid-Mediated Brain Clearance: Insights from Human Studies.

Annual review of physiology·2026
Same journal

The Physiological Challenge of Climate Change for Free-Living Terrestrial Mammals.

Annual review of physiology·2026
Same journal

Light Out of Sight: Signaling Mechanisms for Nonvisual Opsins.

Annual review of physiology·2025
Same journal

From Oil Spills to Air Pollution: The Emergence of Phenanthrene as a Ubiquitous Cardiac Toxicant.

Annual review of physiology·2025
Same journal

The Representation of Nociception and Pain in the Developing Brain.

Annual review of physiology·2025
See all related articles

Hyperpolarization-activated cation channels (HCN channels) are crucial for heart and nerve cell function. This review links HCN channel properties to their diverse physiological roles in cardiac and neuronal activity.

Area of Science:

  • Neuroscience
  • Cardiology
  • Molecular Biology

Background:

  • Hyperpolarization-activated cation currents (Ih) were discovered over 20 years ago in cardiac and nerve cells.
  • These currents are vital for physiological functions like pacemaker activity, resting potentials, and neuronal integration.

Purpose of the Study:

  • To review the relationship between recombinant HCN channel biophysical properties and native Ih characteristics in neurons and cardiac muscle.
  • To explore the physiological functions of Ih and how HCN channel properties contribute to these roles.

Main Methods:

  • Review of existing literature on HCN channel biophysics and gene expression.
  • Correlation of recombinant HCN channel properties with native Ih properties in various tissues.
  • Analysis of physiological roles attributed to Ih currents.

Related Experiment Videos

Main Results:

  • HCN channels encode the hyperpolarization-activated cation nonselective currents (Ih).
  • A strong correlation exists between HCN channel mRNA expression patterns and native Ih properties.
  • HCN channel properties are intrinsically linked to their diverse physiological functions.

Conclusions:

  • The biophysical characteristics of HCN channels directly influence their contribution to cardiac and neuronal excitability.
  • Understanding HCN channel properties is key to comprehending their broad physiological significance.
  • This review highlights the critical role of HCN channels in normal physiological processes.