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Related Experiment Videos

Thioridazine and sexual dysfunction.

J Kotin, D E Wilbert, D Verburg

    The American Journal of Psychiatry
    |January 1, 1976
    PubMed
    Summary

    Thioridazine significantly increases sexual dysfunction in male patients, with ejaculatory issues like retrograde ejaculation being common. Other tranquilizers show a much lower incidence of sexual side effects.

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    Area of Science:

    • Psychopharmacology
    • Sexual Medicine
    • Urology

    Background:

    • Major tranquilizers are widely used in psychiatric treatment.
    • Sexual dysfunction is a potential side effect of psychotropic medications.
    • Thioridazine is a specific antipsychotic medication with known side effect profiles.

    Purpose of the Study:

    • To investigate the incidence of sexual dysfunction in male patients treated with thioridazine.
    • To compare the rates of sexual difficulties between thioridazine and other major tranquilizers.
    • To identify specific types of sexual dysfunctions associated with thioridazine use.

    Main Methods:

    • Retrospective analysis of 57 male patients treated with thioridazine.
    • Comparison group of 64 male patients treated with other major tranquilizers.
    • Assessment of sexual functioning difficulties, including ejaculatory and erectile issues.

    Main Results:

    • A 60% incidence of sexual dysfunction was observed in patients taking thioridazine.
    • Ejaculatory problems, particularly retrograde ejaculation (affecting one-third of patients), were most frequent.
    • Patients on other major tranquilizers had a 25% incidence of sexual difficulties, primarily erectile dysfunction, with no retrograde ejaculation.

    Conclusions:

    • Thioridazine is associated with a high incidence of sexual dysfunction in male patients.
    • Retrograde ejaculation is a notable adverse sexual effect of thioridazine.
    • Clinicians should consider thioridazine's potential for sexual side effects when prescribing.

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