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Cystic Fibrosis and Burkholderia pseudomallei Infection: An Emerging Problem?
David James Holland1, Alison Wesley, Dragana Drinkovic
1LabPlus, Auckland Healthcare, Auckland, New Zealand. dholland@adhb.govt.nz
Abstract:
We recently managed 4 patients with cystic fibrosis who had acquired Burkholderia pseudomallei infection after exposure in a region of endemicity. Person-to-person transmission between 2 siblings may have occurred; otherwise, the evidence suggests that cystic fibrosis may increase the likelihood of infection with this organism, and patients should be warned of this possibility and cautioned to avoid high-risk activities.
Insights
Cystic fibrosis patients acquired Burkholderia pseudomallei infections in endemic areas. Cystic fibrosis may increase infection risk, necessitating warnings and precautions for patients.
Area of Science:
- Infectious Diseases
- Pulmonology
- Microbiology
Background:
- Cystic fibrosis (CF) is a genetic disorder affecting multiple organs.
- Burkholderia pseudomallei causes melioidosis, a serious infectious disease.
- Melioidosis is endemic in tropical regions.
Observation:
- Four patients with cystic fibrosis (CF) developed Burkholderia pseudomallei infection.
- Exposure occurred in a region where the bacterium is endemic.
- Potential person-to-person transmission was noted between siblings.
Findings:
- Cystic fibrosis may predispose individuals to Burkholderia pseudomallei infection.
- The exact transmission routes require further investigation.
- No other risk factors were identified for the majority of cases.
Implications:
- Healthcare providers should be aware of this potential complication in CF patients.
- Patients with cystic fibrosis should be educated about the risks of Burkholderia pseudomallei.
- Cautionary advice regarding high-risk activities in endemic areas is recommended for CF patients.