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Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk

Jianfeng Xu1, S Lilly Zheng, Akira Komiya

  • 1Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. jxu@wfubmc.edu

American Journal of Human Genetics
|December 10, 2002
PubMed

Insights

Common variants in the macrophage scavenger receptor 1 (MSR1) gene are linked to increased prostate cancer risk. These findings suggest MSR1 plays a significant role in prostate carcinogenesis, independent of rare mutations.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Germline mutations in the macrophage scavenger receptor 1 (MSR1) gene have been previously associated with prostate cancer risk.
  • Hereditary prostate cancer (HPC) and non-HPC patient cohorts have shown links to MSR1 gene mutations.

Purpose of the Study:

  • To investigate the association between common variants of the MSR1 gene and prostate cancer susceptibility.
  • To evaluate the role of MSR1 in the development of non-hereditary prostate cancer.

Main Methods:

  • A case-control study involving 301 patients with non-HPC and 250 healthy controls.
  • Analysis of five common MSR1 gene variants and haplotype analysis.

Main Results:

  • Significantly different allele frequencies for all five studied MSR1 variants were observed between prostate cancer cases and controls (P values ranging from .01 to .04).
  • Haplotype analyses revealed significant differences in frequencies (global score test, P=.01).
  • The MSR1 haplotype associated with increased prostate cancer risk did not contain known rare mutations, indicating an independent effect.

Conclusions:

  • Common variants of the MSR1 gene are associated with prostate cancer susceptibility.
  • MSR1 may play a significant role in prostate carcinogenesis, independent of previously identified rare mutations.

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