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[Antiphospholipid syndrome].

J Arvieux1, E Hachulla

  • 1Laboratoire d'immunologie, centre hospitalier universitaire, 5, avenue Foch, 29200 Brest, France. josiane.arvieux@univ.-brest.fr

Annales De Cardiologie Et D'Angeiologie
|December 11, 2002
PubMed
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Antiphospholipid syndrome (APS) is a significant cause of acquired thrombophilia, leading to recurrent thrombosis and obstetric complications. Current management involves warfarin for venous events and aspirin with heparin for obstetric issues.

Area of Science:

  • Immunology
  • Hematology
  • Rheumatology

Background:

  • Antiphospholipid syndrome (APS) is a recognized cause of acquired thrombophilia since 1987.
  • It presents as a primary condition or associated with systemic lupus erythematosus.
  • APS involves recurrent thrombosis (venous/arterial) and obstetric complications in young patients due to antiphospholipid antibodies (aPL).

Purpose of the Study:

  • To review the understanding and management of antiphospholipid syndrome.
  • To highlight the role of antiphospholipid antibodies (aPL) in thrombosis and obstetric complications.
  • To outline current therapeutic strategies for APS patients.

Main Methods:

  • Review of established diagnostic criteria for antiphospholipid antibodies (aPL).
  • Analysis of traditional and emerging understanding of aPL targets (beta 2-glycoprotein I, prothrombin).

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  • Evaluation of standard treatment protocols for thrombotic and obstetric events in APS.

    • Main Results:

    • Antiphospholipid antibodies (aPL) target phospholipid-binding proteins, not phospholipids directly.
    • High risk of recurrence necessitates intensive anticoagulation (warfarin) for venous thromboembolism.
    • Low-dose aspirin and heparin are effective in preventing adverse obstetric outcomes.

    Conclusions:

    • Antiphospholipid syndrome (APS) requires long-term, high-intensity anticoagulation for thrombotic events.
    • Multifaceted management, including vascular risk factor control, is crucial.
    • Combination therapy with aspirin and heparin is a key strategy for managing obstetric complications in APS.