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Updated: Aug 2, 2026
In situ Transverse Rectus Abdominis Myocutaneous Flap: A Rat Model of Myocutaneous Ischemia Reperfusion Injury
Published on: June 8, 2013
[The effect of basic fibroblast growth factor (bFGF) on neovascularization and prefabricated flap survival]
Xukai Wang1, Dong Yan, Yongquan Liu
1Department of Plastic Surgery, First Hospital, China Medical University, Shenyang 110001, China.
Objective:
To observe the effect of basic fibroblast growth factor (bFGF) on neovascularization and prefabricated flap survival.
Methods:
Male New-Zealand rabbits weighting 2.0-2.5 kg were used in this study. The experimental model used a prefabricated neck flap, supplied by the transferred and implanted central vascular bundle of the ear. 9 micrograms bFGF and 0.2 ml of normal saline was instilled in the vascular pedicle of the experimental and the control group respectively. After 1, 2, 3 weeks of operation, the neovascularization was studied by confocal laser scanning microscope (CLSM) and flap survival was observed.
Results:
The neovascularization and survival of the prefabricated flap was different in the experimental and the control groups. The experimental group was better than the control group.
Conclusion:
bFGF treatment improved sprouting of the implanted vessel and the prefabricated flap survival.
