Related Experiment Video
Updated: Aug 6, 2026

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
Published on: July 28, 2010
[Free radical processes and their role in pathogenesis of some gastrointestinal diseases (part 1)]
Abstract:
The authors studied enzymatic and non-enzymatic modes of active oxygen forms formation, mechanisms of their damage to live cells, in particular, initiation of free radical lipid peroxidation; investigated anti- and prooxidant systems of body defense responsible for balance between appearance, metabolism and utilization of active oxygen forms. Impairment of this balance converts physiological processes into pathological ones. Peculiarities of free radical processes and their role in pathogenesis of some gastrointestinal diseases are described.
Related Concept Videos
Radical Reactivity: Overview
Radical Autoxidation
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Gastritis II: Pathophysiology
Inflammatory Bowel Disease II: Ulcerative Colitis
Inflammatory Bowel Disease III: Crohn's Disease

