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Thiazide-induced lichenoid photosensitivity.

G A Johnston1

  • 1Department of Dermatology, Leicester Royal Infirmary, Leicester, UK. gjohnston@uhl-tr.nhs.uk

Clinical and Experimental Dermatology
|December 11, 2002
PubMed
Summary

A 77-year-old man experienced a severe light-sensitive skin reaction (photosensitive eruption) from thiazide diuretics used for heart failure. Histological examination confirmed lichenoid lesions, which resolved after discontinuing the medication.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Internal Medicine

Background:

  • Thiazide diuretics are commonly prescribed for managing heart failure.
  • Photosensitivity reactions are a known, albeit uncommon, side effect of thiazide diuretics.
  • Lichenoid drug eruptions can occur, but are not typically associated with photosensitivity.

Observation:

  • A 77-year-old male patient presented with a widespread, photosensitive skin eruption.
  • The patient was concurrently taking thiazide diuretics for treatment of heart failure.
  • The observed skin lesions exhibited a lichenoid morphology.

Findings:

  • Histological examination confirmed the lichenoid nature of the skin lesions.
  • The photosensitive eruption resolved completely upon cessation of the thiazide diuretic.
  • This case represents a histologically confirmed instance of a lichenoid photosensitive eruption linked to thiazide use.

Implications:

  • This case highlights an unusual presentation of thiazide-induced photosensitivity.
  • It suggests that thiazide diuretics can induce lichenoid changes in sun-exposed skin.
  • Further investigation into the mechanisms of drug-induced photosensitivity and lichenoid reactions is warranted.

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