Related Experiment Videos
Neutralization titres and vertical HIV-1 transmission
V Bongertz1, C I Costa, V G Veloso
1AIDS and Molecular Immunology Laboratory, Department of Immunology, IOC, FIOCRUZ, Brazil. bongertz@ioc.fiocruz.br
Scandinavian Journal of Immunology
|December 11, 2002
Abstract:
Replication of the human immunodeficiency virus type 1 (HIV-1) isolate MN in CEM cells was less neutralized by the plasma from the mothers of infected children (MIC) in comparison with the plasma from the mothers of uninfected children (MUC). Significantly higher neutralization titres were observed for the sera from MUCs compared with MICs, and only the sera from MUC showed 100% neutralization of the HIV-1 MN strain. We suggest that a simple neutralization assay as described here could be useful in prognostic analyses.