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Alpha-chymotrypsin glaucoma.

H W Skalka

    Annals of Ophthalmology
    |February 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Alpha-chymotrypsin use in cataract surgery did not elevate ocular hypertension. Reduced enzyme amounts and shorter wait times are effective and may prevent enzyme glaucoma, especially in non-diabetic patients.

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    Area of Science:

    • Ophthalmology
    • Surgical Science

    Background:

    • Intracapsular cataract extraction is a common surgical procedure.
    • Postoperative ocular hypertension is a potential complication following cataract surgery.

    Purpose of the Study:

    • To evaluate the effect of alpha-chymotrypsin on postoperative ocular hypertension after intracapsular cataract extraction.
    • To determine optimal enzyme dosage and timing for effective zonulysis while minimizing risks.

    Main Methods:

    • Retrospective review of 141 eyes from 115 patients undergoing uncomplicated intracapsular cataract extraction.
    • Analysis of postoperative ocular pressure in relation to alpha-chymotrypsin use, dosage, and patient factors like diabetes.

    Main Results:

    • Alpha-chymotrypsin did not increase the incidence of significant postoperative ocular hypertension.

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  • Reduced enzyme amounts and shorter waiting periods proved adequate for zonulysis and protective against enzyme glaucoma.
  • Non-diabetic patients receiving the enzyme showed a lower incidence of postoperative ocular hypertension compared to those not receiving it.
  • Diabetes mellitus was identified as the sole factor associated with an increased risk of postoperative hypertensive responses.

    • Conclusions:

    • Current practices using alpha-chymotrypsin in intracapsular cataract extraction are safe regarding postoperative ocular hypertension.
    • Optimized enzyme use (smaller amounts, shorter duration) is effective and reduces the risk of enzyme glaucoma.
    • Diabetic status is a critical factor influencing postoperative ocular pressure response.