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Practical assay and molecular mechanism of aggregation inhibitors of beta-amyloid

S Akikusa1, K-I Watanabe, E Horikawa

  • 1National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan.

The Journal of Peptide Research : Official Journal of the American Peptide Society
|December 11, 2002
PubMed

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Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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