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Systemic sclerosis.

Gabriele Valentini1, Carol Black

  • 1Unità Operativa di Reumatologia, Seconda Università degli Studi di Napoli, Via Pansini, 5 - 80131, Naples, Italy. gabriele.valentini@unina2.it

Best Practice & Research. Clinical Rheumatology
|December 11, 2002
PubMed
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Systemic sclerosis (SSc) exhibits significant patient variability and geographical differences in prevalence. This review analyzes SSc classification, epidemiology, and factors influencing survival, offering insights into this complex autoimmune disease.

Area of Science:

  • Rheumatology
  • Immunology
  • Epidemiology

Background:

  • Systemic sclerosis (SSc) is a complex autoimmune disease characterized by significant patient-to-patient variability.
  • Its prevalence and incidence vary globally and across ethnic groups, necessitating detailed epidemiological analysis.

Purpose of the Study:

  • To analyze classification and subset criteria for Systemic sclerosis.
  • To elucidate global prevalence and incidence variations.
  • To discuss genetic, environmental, and pregnancy-related factors influencing SSc.

Main Methods:

  • Literature review and analysis of epidemiological studies.
  • Examination of genetic and environmental risk factors.
  • Discussion of microchimerism and pregnancy-related factors.

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Main Results:

  • Systemic sclerosis predominantly affects females, with ratios ranging from 3:1 to 8:1.
  • Geographical and ethnic variations in SSc prevalence are significant.
  • Recent data indicate improved survival rates over the past 15 years.

Conclusions:

  • Understanding SSc variability is crucial for accurate classification and management.
  • Further research into genetic, environmental, and microchimerism factors is warranted.
  • Improved survival highlights advances in SSc treatment and care.