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Bacterial Phylum Chlamydiae01:29

Bacterial Phylum Chlamydiae

291
The phylum Chlamydiae or Chlamydiota is composed of a single order, Chlamydiales. This phylum consists entirely of obligate intracellular parasites that infect eukaryotic hosts. While human pathogens within this group have been studied extensively, the phylum encompasses many species capable of interacting with various eukaryotic organisms. Members of Chlamydiae are typically small cocci, approximately 0.5 μm in diameter, and exhibit a distinctive developmental cycle. As is characteristic...
291
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

352
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
352
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

285
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
285
Bacterial Phylum Tenericutes01:24

Bacterial Phylum Tenericutes

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The phylum Tenericutes, which includes the single class Mollicutes, comprises bacteria that lack cell walls. The term "Mollicutes" derives from the Latin word mollis, meaning "soft." These organisms are among the smallest known and are commonly referred to as mycoplasmas due to the prominence of the genus Mycoplasma, which includes well-known human pathogens. Despite their inability to stain gram-positively (a result of their lack of cell walls), mycoplasmas are phylogenetically related to the...
291
Bacterial Phylum Spirochaetes01:30

Bacterial Phylum Spirochaetes

343
Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased...
343
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

649
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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Related Experiment Video

Updated: Dec 1, 2025

Markerless Gene Deletion by Floxed Cassette Allelic Exchange Mutagenesis in Chlamydia trachomatis
10:35

Markerless Gene Deletion by Floxed Cassette Allelic Exchange Mutagenesis in Chlamydia trachomatis

Published on: January 30, 2020

7.0K

Chlamydia trachomatis - the agent.

Roberto Cevenini1, Manuela Donati, Vittorio Sambri

  • 1Sezione di Microbiologia, DMCSS, University of Bologna, Policlinico S. Orsola, Via Massarenti 9, 40138, Bologna, Italy.

Best Practice & Research. Clinical Obstetrics & Gynaecology
|December 11, 2002
PubMed
Summary

Chlamydiae are obligate intracellular bacteria. Research on Chlamydia trachomatis, including its genome, reveals new insights into its biology and metabolic pathways.

Area of Science:

  • Microbiology
  • Bacteriology
  • Infectious Diseases

Background:

  • Chlamydiae are obligate intracellular bacteria that infect eukaryotic cells.
  • Human pathogenic species include Chlamydia trachomatis, C. psittaci, and C. pneumoniae.
  • Chlamydia trachomatis targets genital and conjunctival epithelia, with 19 serovars primarily causing urogenital tract infections.

Purpose of the Study:

  • To revise current understanding of Chlamydia trachomatis biology and metabolic pathways.
  • To identify novel proteins associated with Chlamydia trachomatis.

Main Methods:

  • Analysis of the complete 1000-kb chromosome sequence of C. trachomatis.
  • Investigation of genes on the 7.5-kb cryptic plasmid.
  • Genomic analysis to revise biological concepts and metabolic pathways.

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Forward Genetic Approaches in Chlamydia trachomatis
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Forward Genetic Approaches in Chlamydia trachomatis

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A Human Fallopian Tube Model for Investigation of C. trachomatis Infections
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A Human Fallopian Tube Model for Investigation of C. trachomatis Infections

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Related Experiment Videos

Last Updated: Dec 1, 2025

Markerless Gene Deletion by Floxed Cassette Allelic Exchange Mutagenesis in Chlamydia trachomatis
10:35

Markerless Gene Deletion by Floxed Cassette Allelic Exchange Mutagenesis in Chlamydia trachomatis

Published on: January 30, 2020

7.0K
Forward Genetic Approaches in Chlamydia trachomatis
09:03

Forward Genetic Approaches in Chlamydia trachomatis

Published on: October 23, 2013

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A Human Fallopian Tube Model for Investigation of C. trachomatis Infections
09:11

A Human Fallopian Tube Model for Investigation of C. trachomatis Infections

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Main Results:

  • The complete genome sequence of C. trachomatis has been elucidated.
  • Novel proteins and revised metabolic pathways have been identified.
  • Understanding of chlamydial biology has been advanced through genomic insights.

Conclusions:

  • Genome sequencing has significantly advanced our knowledge of Chlamydia trachomatis.
  • New biological concepts and metabolic pathways are now recognized.
  • Further research into novel proteins may reveal new therapeutic targets.