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Sympathetic and cardiac baroreflex function in panic disorder.

Elisabeth A Lambert1, Jane Thompson, Markus Schlaich

  • 1Human Neurotransmitter Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia. elisabeth.lambert@baker.edu.au

Journal of Hypertension
|December 11, 2002
PubMed
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Patients with panic disorder show heightened arterial baroreflex control of sympathetic nerves, potentially linked to cardiac risks. This enhanced sympathetic nerve reactivity may be a key trait in panic disorder.

Area of Science:

  • Cardiology
  • Neuroscience
  • Psychiatry

Background:

  • Panic disorder is associated with increased cardiac risk and hypertension.
  • Sympathetic nervous system activation is a potential underlying cause.
  • This study investigates baroreflex control in panic disorder patients.

Purpose of the Study:

  • To evaluate arterial baroreflex control of vascular sympathetic nervous outflow.
  • To assess cardiac baroreflex function in panic disorder patients.

Main Methods:

  • Microneurographic recording of muscle sympathetic nerve activity (MSNA) and blood pressure (BP).
  • Assessed arterial baroreflex control of MSNA and cardiac baroreflex sensitivity.
  • Utilized Spielberger's anxiety inventory for anxiety assessment.

Related Experiment Videos

Main Results:

  • Panic disorder patients exhibited significantly steeper arterial baroreflex control of MSNA compared to controls.
  • Higher state and trait anxiety scores were observed in panic disorder patients.
  • No significant difference in cardiac baroreflex sensitivity was found between groups.

Conclusions:

  • Panic disorder is characterized by enhanced arterial baroreflex gain of MSNA.
  • Cardiac baroreflex sensitivity remains unchanged in panic disorder.
  • Increased sympathetic nerve reactivity may be a trait in panic disorder, potentially relating to cardiac risk.