Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Communicating hydrocephalus. Cisternographic and neuropathologic studies.

D L Price, A E James, E Sperber

    Archives of Neurology
    |January 11, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A photoelectric colorimetric assay for digitoxin by comparison with a standard powder.

    Journal of the American Pharmaceutical Association. American Pharmaceutical Association·2010
    Same author

    BRE is an antiapoptotic protein in vivo and overexpressed in human hepatocellular carcinoma.

    Oncogene·2007
    Same author

    Multipotent neural precursors express neural and hematopoietic factors, and enhance ex vivo expansion of cord blood CD34+ cells, colony forming units and NOD/SCID-repopulating cells in contact and noncontact cultures.

    Leukemia·2004
    Same author

    Cobblestone area-forming cells, long-term culture-initiating cells and NOD/SCID repopulating cells in human neonatal blood: a comparison with umbilical cord blood.

    Bone marrow transplantation·2002
    Same author

    Preclinical ex vivo expansion of cord blood hematopoietic stem and progenitor cells: duration of culture; the media, serum supplements, and growth factors used; and engraftment in NOD/SCID mice.

    Transfusion·2002
    Same author

    Delivery and scavenging system for small animal inhalational anesthesia.

    The Journal of surgical research·2001

    This study details chronic communicating hydrocephalus in dogs, revealing early pressure increases followed by normal pressures and severe ependymal damage in chronic stages. Findings correlate pathological changes with imaging and cerebrospinal fluid pressure.

    Area of Science:

    • Neurology
    • Pathology
    • Veterinary Medicine

    Background:

    • Hydrocephalus is a condition characterized by abnormal accumulation of cerebrospinal fluid (CSF) within the brain's ventricles.
    • Understanding the pathological progression of hydrocephalus is crucial for developing effective treatments.

    Purpose of the Study:

    • To investigate the pathological changes in the ventricular wall during the development of chronic communicating hydrocephalus.
    • To correlate these pathological findings with diagnostic imaging and cerebrospinal fluid (CSF) pressure measurements.

    Main Methods:

    • Chronic communicating hydrocephalus was induced in adult dogs by injecting silastic into the subarachnoid space.
    • Electron microscopy was employed to examine the cellular and tissue alterations.

    Related Experiment Videos

  • Cisternography and CSF pressure monitoring were performed to assess hydrocephalus progression.

    • Main Results:

    • Early hydrocephalus showed increased CSF pressure, ventricular entry, and ependymal stretching with subependymal fluid accumulation.
    • Chronic hydrocephalus presented with normal CSF pressure but persistent ventricular radioactivity on cisternograms.
    • Severe ependymal damage, enlarged extracellular spaces in white matter, and axonal/myelin sheath degeneration were observed in chronic cases.

    Conclusions:

    • The study elucidates the distinct pathological stages of experimental communicating hydrocephalus in dogs.
    • Chronic hydrocephalus is associated with significant structural damage to the ependyma and underlying white matter, even with normalized CSF pressure.