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Related Experiment Videos

Managing sarcopenia with progressive resistance exercise training.

K E Yarasheski1

  • 1Kevin E.Yarasheski, PhD, Washington University Medical School, Division of Metabolism, Endocrinology and Diabetes, 660 South Euclid Avenue BOX 8127, St. Louis, MO 63110. Ph# 314-362-8173. FAX# 314-362-8188.

The Journal of Nutrition, Health & Aging
|December 11, 2002
PubMed
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Aging impairs skeletal muscle protein synthesis and strength. Progressive resistance exercise training effectively restores muscle quality and quantity in older adults, combating frailty and disability.

Area of Science:

  • Gerontology
  • Skeletal Muscle Physiology
  • Exercise Science

Background:

  • Advancing age is associated with detrimental changes in skeletal muscle protein characteristics.
  • These age-related alterations reduce muscle strength, power, and contribute to frailty and disability.
  • Impaired muscle protein quantity and quality increase healthcare costs and risk of falls and fractures.

Purpose of the Study:

  • To review the age-associated changes in skeletal muscle protein.
  • To examine the evidence supporting progressive resistance exercise training as a countermeasure.
  • To discuss the pathogenesis of age-related muscle impairments.

Main Methods:

  • Review of scientific literature on aging, skeletal muscle physiology, and exercise.

Related Experiment Videos

  • Analysis of studies investigating the effects of progressive resistance exercise on muscle protein.
  • Examination of proposed mechanisms for age-related muscle decline.

    • Main Results:

    • Aging reduces synthesis rates of contractile, mitochondrial, and enzyme proteins in skeletal muscle.
    • Age-related muscle impairments include decreased strength, power, and altered protein expression.
    • Progressive resistance exercise training demonstrates efficacy in restoring muscle protein quantity and quality.

    Conclusions:

    • Progressive resistance exercise is a potent non-pharmacologic therapy for age-related muscle impairments.
    • Muscle proteins remain adaptable to exercise stimuli even in older adults.
    • Exercise training can mitigate frailty, disability, and associated healthcare costs in aging populations.