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p21 gene codon 31 polymorphism is associated with bladder cancer.
Wen-Chi Chen1, Hsi-Chin Wu, Cheng-Der Hsu
1Department of Urology, China Medical College Hospital, School of Medicine, China Medical College, Taichung, Taiwan.
Urologic Oncology
|December 12, 2002
Summary
The p21 gene codon 31 polymorphism is linked to bladder cancer risk and progression. The arginine form increases the risk of developing bladder cancer and is associated with tumor grade.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- The p21 gene plays a role in cell apoptosis, progression, and malignancies.
- Previous research suggested p21 is linked to cancer formation but not tumor grade.
Purpose of the Study:
- To investigate the p21 gene codon 31 polymorphism as a potential genetic marker for bladder cancer.
- To determine the association of this polymorphism with bladder cancer development and progression.
Main Methods:
- Analysis of p21 codon 31 polymorphism distribution in 53 Taiwanese bladder cancer patients and 119 healthy controls.
- Utilized polymerase chain reaction-based restriction analysis to study the association.
Main Results:
- A significant difference in p21 codon 31 polymorphism was observed between cancer patients and controls (p < 0.01).
- The arginine form of the polymorphism was more prevalent in cancer patients (OR = 2.03).
- The distribution of this polymorphism differed significantly between non-invasive and invasive bladder cancer (p < 0.05), with serine heterozygote more common in invasive cases.
Conclusions:
- The p21 gene codon 31 polymorphism is associated with bladder cancer.
- Individuals with the arginine form allele have an increased risk of developing bladder cancer.
- The study indicates a link between p21 gene polymorphism and tumor grade, contrary to previous assumptions.