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The pontine micturition centres.

Derek J Griffiths¹

¹Division of Geriatric Medicine, University of Pittsburgh, PA 15213, USA. griffithsdj@msx.dept-med.pitt.edu

Scandinavian Journal of Urology and Nephrology. Supplementum

|December 12, 2002

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Recent literature shows the pontine M-region is crucial for voiding control in cats and humans. The L-region likely aids general sphincter control, but its human homolog remains unclear.

Area of Science:

Neuroscience
Urology
Neuroanatomy

Background:

The pontine tegmentum contains regions involved in lower urinary tract control.
Two distinct areas, the M- and L-regions, have been postulated to play roles in micturition and sphincter function.

Purpose of the Study:

To review and synthesize recent literature on the functional roles of the M- and L-regions in the pons.
To clarify the specific contributions of these pontine regions to lower urinary tract control.

Main Methods:

Literature review of studies employing stimulation and lesion experiments in cats.
Analysis of acute chemical stimulation and blocking experiments in rats.
Inclusion of functional brain imaging data (PET scans) from human studies.

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Main Results:

The M-region in cats is identified as a specific and essential area for voiding, homologous to Barrington's micturition center in humans.
This M-region serves as the origin for the final common pathway controlling the bladder and striated sphincter.
The L-region in cats is part of a broader area involved in various sphincter control functions, not solely micturition.

Conclusions:

The pontine M-region is a critical, specific center for micturition and coordinated bladder-sphincter function in cats and humans.
The L-region's role appears broader, related to general sphincter control, with its human homolog not yet well-defined.
Further research is needed to fully establish the human homolog of the L-region and its precise functions.