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Updated: Jul 8, 2026
06:44
From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
Published on: March 24, 2018
The use of polymer heteronuclei for crystalline polymorph selection
Meidong Lang1, Adam L Grzesiak, Adam J Matzger
1Department of Chemistry and the Macromolecular Science and Engineering Program, The University of Michigan, Ann Arbor, MI 48109-1055, USA.
Journal of the American Chemical Society
|December 12, 2002
Summary
This study introduces a novel method using polymer heteronuclei for controlled crystalline polymorph production. This technique offers a new approach for selecting specific pharmaceutical polymorphs like acetaminophen and carbamazepine.
Area of Science:
- Materials Science
- Chemical Engineering
- Pharmaceutical Science
Background:
- Crystalline polymorphs significantly impact drug efficacy and manufacturability.
- Current polymorph selection methods can be limited by solvent and temperature constraints.
- Controlling crystallization is crucial for pharmaceutical development.
Purpose of the Study:
- To present a new method for producing specific crystalline polymorphs from solution.
- To demonstrate the application of this method for pharmaceutical polymorph selection.
- To establish a flexible approach for polymorph control.
Main Methods:
- Utilizing a diverse set of polymer heteronuclei as nucleation sites.
- Applying the method to the crystallization of acetaminophen and carbamazepine.
- Varying polymer heteronuclei to achieve targeted polymorph production.
Main Results:
- Successful production of crystalline polymorphs using polymer heteronuclei.
- Demonstrated selective polymorph crystallization for acetaminophen and carbamazepine.
- Showcased the versatility of the polymer heteronucleus in directing crystal form.
Conclusions:
- The described method offers a new paradigm for polymorph selection.
- This approach allows for process-driven solvent and temperature choices.
- Tailoring the polymer heteronucleus enables specific polymorph generation.
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