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Updated: Jul 8, 2026

Spatial Separation of Molecular Conformers and Clusters
Published on: January 9, 2014
Sensitive through-space dipolar correlations between nuclei of small organic molecules by partial alignment in a
1Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Campus Box B111, 4200 East Ninth Avenue, Denver, CO 80262, USA. brad.bendiak@uchsc.edu
Abstract:
Through-space residual dipolar correlations in NMR spectra can be measured between nuclei of small organic molecules by partially aligning them with respect to the magnetic field in a pure deuterated liquid solvent, 4-pentyl-4'-cyanobiphenyl. A simple temperature change of this liquid phase enables spectra to be compared between samples under isotropic tumbling conditions and weakly oriented anisotropic states. This should provide access of a number of small nonpolar molecules to more sensitive through-space nuclear correlations than possible through NOE experiments, depending on the net orientation of specific nuclear pairs with respect to the magnetic field and the specific coherence transfers employed.
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