Sensitive through-space dipolar correlations between nuclei of small organic molecules by partial alignment in a

Brad Bendiak1

  • 1Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Campus Box B111, 4200 East Ninth Avenue, Denver, CO 80262, USA. brad.bendiak@uchsc.edu

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Nuclear Stability

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Chemical Bonds


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Types of Chemical Bonds
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Nuclear Overhauser Enhancement (NOE)

Irradiation of a spin-active nucleus causes an increase or decrease in the signal intensity of neighboring nuclei that are not necessarily chemically bonded or involved in J-coupling. This phenomenon, called the nuclear Overhauser enhancement (NOE), results from through-space interactions between the nuclear spins. The NOE effect decreases with increasing internuclear distance and is generally not observed beyond 4 angstroms. In NOE, dipole-dipole interactions between neighboring spin-active...