Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gender-specific programming of insulin secretion and action.

M C Sugden1, M J Holness

  • 1Department of Diabetes and Metabolic Medicine, Division of General and Developmental Medicine, Barts and the London, Queen Mary's School of Medicine and Dentistry, University of London, Mile End Road, London E1 4NS, UK.

The Journal of Endocrinology
|December 12, 2002
PubMed
Summary

Maternal protein restriction during pregnancy and lactation leads to insulin resistance in male offspring. Glucose tolerance is maintained, but insulin secretion and sensitivity show gender-specific changes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A key role for interferon regulatory factors in mediating early-life metabolic defects in male offspring of maternal protein restricted rats.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2014
Same author

The AMPK-SIRT signaling network regulates glucose tolerance under calorie restriction conditions.

Life sciences·2014
Same author

Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients.

Diabetologia·2013
Same author

The involvement of PPARs in the causes, consequences and mechanisms for correction of cardiac lipotoxicity and oxidative stress.

Current molecular pharmacology·2011
Same author

Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function.

Diabetologia·2011
Same author

Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically-obese db/db mice.

Diabetes, obesity & metabolism·2011

Area of Science:

  • Endocrinology
  • Nutritional Science
  • Metabolic Research

Background:

  • Maternal nutrition during gestation and lactation significantly impacts offspring metabolic health.
  • Early-life nutritional insults, such as protein restriction, can have long-lasting effects on glucose homeostasis.
  • Understanding gender-specific responses to early-life nutrition is crucial for metabolic disease prevention.

Purpose of the Study:

  • To investigate the long-term effects of maternal protein restriction on insulin secretion and glucose tolerance in male and female offspring.
  • To determine if protein restriction during specific developmental windows (gestation, lactation, or adulthood) influences metabolic outcomes differently.
  • To elucidate gender-specific differences in metabolic adaptations to early-life protein restriction.

Main Methods:

Related Experiment Videos

  • Offspring from rat dams fed either 20% or 8% protein diets during pregnancy and lactation were studied.
  • Offspring were exposed to different dietary protein levels from conception, weaning, or adulthood.
  • Insulin secretion, glucose tolerance, insulin resistance index, and insulinogenic index were assessed in adult offspring.

Main Results:

  • Protein restriction from conception to adulthood suppressed insulin in males but increased basal insulin if limited to early life.
  • Early or sustained protein restriction did not affect post-absorptive insulinaemia in females, which was lower than in males.
  • Males exposed to protein restriction during gestation and lactation alone showed increased insulin resistance and insulinogenic index, while females exhibited compensated insulin sensitivity.

Conclusions:

  • Early-life protein restriction, particularly during gestation and lactation, induces gender-specific insulin resistance and hyperinsulinaemia in adult male rats.
  • While glucose tolerance is maintained, the metabolic adaptations to protein restriction show significant sexual dimorphism.
  • These findings highlight the critical role of maternal nutrition during development in shaping long-term metabolic health and underscore gender-specific vulnerabilities.