Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lung function decline in bronchial asthma.

Fabio Cibella1, Giuseppina Cuttitta, Vincenzo Bellia

  • 1Istituto di Fisiopatologia Respiratoria del C. N. R., via U. La Malfa 153, I-90146 Palermo, Italy. cibella@ifr.pa.cnr.it

Chest
|December 12, 2002
PubMed
Summary

Lung function decline in asthma patients is linked to baseline lung capacity, disease duration, and lung function variability. Younger asthmatics with poorer baseline function experience faster lung function decline.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparing the Effect of Scaling and Polishing on Nine Oral Health and Dental Aesthetic Measures between Current and Never Smokers from the SMILE Study Cohort.

Journal of dentistry·2026
Same author

A BDE-47/estrone mixture modulates macrophage immune responses and miRNA networks, impairs intestinal barrier integrity in vitro, and alters circulating miRNAs and tight junction expression in vivo.

Ecotoxicology and environmental safety·2026
Same author

The SMILE study cohort: Baseline comparison of oral health and dental aesthetics among smokers in Italy, Poland, Moldova, and Indonesia.

Journal of dentistry·2025
Same author

Improved aerobic capacity in a randomized controlled trial of noncombustible nicotine and tobacco products.

Scientific reports·2025
Same author

Influence of prenatal hexachlorobenzene, PCB and selenium levels on growth trajectories in the first year of life: Findings from the NEHO birth cohort.

Environment international·2024
Same author

Guardians under Siege: Exploring Pollution's Effects on Human Immunity.

International journal of molecular sciences·2024

Area of Science:

  • Pulmonology
  • Respiratory Medicine
  • Clinical Research

Background:

  • Asthma is a chronic respiratory disease characterized by variable airflow limitation.
  • Longitudinal studies are crucial for understanding disease progression and predicting outcomes in asthma patients.

Purpose of the Study:

  • To evaluate the longitudinal changes in lung function, specifically forced expiratory volume in one second (FEV1), in asthma patients.
  • To identify factors influencing the rate of FEV1 decline over time.

Main Methods:

  • 142 asthma patients were studied over a 5-year period with FEV1 measurements every 3 months.
  • FEV1 values were normalized for height to allow for inter-subject comparisons.
  • The impact of age, baseline FEV1, disease duration, and FEV1 variability on FEV1 change rate was assessed.

Related Experiment Videos

Main Results:

  • FEV1 demonstrated a linear decline with aging in all subjects, with a median decay of 40.9 mL/yr for a 1.65m individual.
  • FEV1 decay was steeper in younger males and significantly influenced by age and sex.
  • Higher FEV1 decay was observed in younger asthmatics with poorer baseline lung function.
  • Longer disease duration correlated with a slower FEV1 decline, while higher FEV1 variability was linked to accelerated decline.

Conclusions:

  • Baseline FEV1, disease duration, and FEV1 variability are significant predictors of FEV1 decline in asthma.
  • Younger asthmatics with poorer baseline lung function experience a more rapid FEV1 decline.