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Acid reflux and asthma.

Susan M Harding1

  • 1Division of Pulmonary, Allergy, and Critical Care Medicine, The University of Alabama at Birmingham, 35294, USA. sharding@uab.edu

Current Opinion in Pulmonary Medicine
|December 12, 2002
PubMed
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Asthma patients often develop gastroesophageal reflux (GER), increasing hospitalization risk. Asthma medications like albuterol and prednisone may worsen GER, suggesting reflux therapy could benefit selected asthma patients.

Area of Science:

  • Pulmonology and Gastroenterology
  • Investigating the interplay between respiratory and digestive system disorders.

Background:

  • Asthma patients exhibit a higher prevalence of gastroesophageal reflux (GER) compared to the general population.
  • GER in asthmatics is linked to an increased risk of asthma-related hospitalizations.
  • Specific asthma medications may contribute to GER development.

Purpose of the Study:

  • To explore the relationship between asthma and gastroesophageal reflux (GER).
  • To examine the potential impact of asthma medications on GER.
  • To assess the potential benefits of GER therapy on asthma outcomes.

Main Methods:

  • Review of recent clinical investigations on asthma and GER.
  • Analysis of the effects of asthma medications (inhaled albuterol, oral prednisone) on esophageal function.

Related Experiment Videos

  • Correlation of respiratory symptoms with esophageal acid events.

    • Main Results:

    • Asthma medications, such as inhaled albuterol and oral prednisone, can negatively affect esophageal function and increase acid exposure.
    • Respiratory symptoms in asthma patients correlate with esophageal acid events.
    • The role of neurogenic inflammation in asthma and its connection to GER is an area of ongoing research.

    Conclusions:

    • Gastroesophageal reflux (GER) is more prevalent in asthma patients and associated with worse outcomes.
    • Asthma medications may promote GER development by affecting lower esophageal sphincter pressure and acid contact time.
    • While GER therapy may improve asthma outcomes in some patients, further rigorous clinical trials are needed.