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Fibrinolysis, fibrinogen and trhombin time in newborns
Insights
Blocking in vitro fibrinolysis in newborns reduced abnormal euglobulin clot lysis time but did not affect fibrinogen or thrombin time. Prolonged thrombin time in neonates is not preventable by inhibiting in vitro fibrinolysis.
Area of Science:
- Neonatal Hematology
- Hemostasis and Thrombosis Research
Background:
- Neonatal blood samples often exhibit prolonged thrombin time and euglobulin clot lysis time, suggesting potential coagulation abnormalities.
- In vitro fibrinolysis may contribute to these observed coagulation changes in newborns.
Purpose of the Study:
- To investigate whether inhibiting in vitro fibrinolysis can prevent prolonged thrombin time in newborn infants.
- To explore the role of fibrinolysis in neonatal coagulation parameters.
Main Methods:
- Comparative experiments on blood samples from newborn infants (up to 12 hours old).
- Samples were collected both with and without a fibrinolysis-blocking agent.
- Analysis included euglobulin clot lysis time, fibrinogen levels, and thrombin time.
Main Results:
- Inhibition of in vitro fibrinolysis decreased the frequency of abnormal euglobulin clot lysis time.
- No significant differences were observed in fibrinogen levels between groups.
- The frequency and degree of prolonged thrombin time remained unchanged despite blocking fibrinolysis.
Conclusions:
- Blocking in vitro fibrinolysis does not prevent the prolongation of thrombin time in newborn infants.
- The findings suggest that prolonged thrombin time in neonates may be related to factors other than in vitro fibrinolysis, potentially involving abnormal fetal fibrinogen.
Abstract:
Comparative experiments were made on blood samples collected with and without addition of a potent fribinolysis-blocking agent in newborn infants aged up to 12 h. Prevention of the in vitro fibrinolysis resulted in a diminished frequency of an abnormal euglobulin clot lysis time, but there was no significant difference in fibrinogen levels and in the frequency and degree of a prolonged thrombin time. These results indicate that the prolongation of thrombin time in newborn infants cannot be prevented by blocking the in vitro fibrinolysis. The significance of these findings is discussed with regard to the possible existence of an abnormal 'fetal fibrinogen'.