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Effects of four antihypertensive monotherapies on cardiac mass and function in hypertensive patients with left

Drago Rakić1, Zvonko Rumboldt, Jugoslav Bagatin

  • 1Department of Internal Medicine, Split University Hospital and School of Medicine, Split, Croatia. drago.rakic@st.hinet.hr

Croatian Medical Journal
|December 12, 2002
PubMed

Insights

Four antihypertensive drugs effectively reduced left ventricular (LV) hypertrophy and blood pressure in patients with hypertension. All medications showed comparable efficacy in lowering LV mass, with no significant differences observed between them.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Hypertension is a major risk factor for left ventricular (LV) hypertrophy.
  • LV hypertrophy is associated with increased cardiovascular morbidity and mortality.
  • Several antihypertensive medications are available, but their comparative effects on LV mass are not fully elucidated.

Purpose of the Study:

  • To compare the efficacy of four antihypertensive drugs in reducing left ventricular (LV) mass in patients with hypertension.
  • To assess the effects of indapamide, nicardipine, propranolol, and chlorthalidone on blood pressure, LV mass, and LV function.

Main Methods:

  • A randomized, double-blind, prospective study involving 80 hypertensive patients with confirmed LV hypertrophy.
  • Patients received one of four antihypertensive medications: indapamide, nicardipine, propranolol, or chlorthalidone for 6 months.
  • Blood pressure, LV mass, and LV function were assessed using electrocardiography and echocardiography.

Main Results:

  • No significant differences in antihypertensive effects were observed among the four drugs.
  • All medications significantly reduced LV mass, with reductions ranging from 7.9% to 10.1%.
  • Diastolic function showed some improvement, but systolic function did not improve with LV hypertrophy regression.

Conclusions:

  • Indapamide, nicardipine, propranolol, and chlorthalidone are equally effective in controlling hypertension and reducing LV hypertrophy.
  • These findings suggest that multiple antihypertensive monotherapies can achieve comparable outcomes in managing hypertensive heart disease.
Abstract

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