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Updated: Sep 28, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
[Off-pump coronary artery bypass grafting/beating coronary artery bypass grafting for a patient with low left
1Department of Surgery, Toyama Medical and Pharmaceutical University, Toyama, Japan.
Insights
Beating coronary artery bypass grafting is now feasible for patients with severely reduced left ventricular ejection fraction (LVEF). This surgical approach significantly improved LVEF in a patient previously considered ineligible for conventional bypass surgery.
Area of Science:
- Cardiovascular Surgery
- Cardiac Anesthesia
- Cardiology
Background:
- Conventional coronary artery bypass grafting (CABG) is typically contraindicated in patients with a left ventricular ejection fraction (LVEF) below 20%.
- Off-pump CABG (OPCAB) and beating CABG have emerged as potentially safer alternatives for high-risk patients due to lower complication rates.
Observation:
- A 47-year-old male patient with a severely impaired LVEF of 9.3% underwent beating coronary artery bypass grafting.
- Percutaneous cardio-pulmonary support (PCPS) was utilized during the procedure to facilitate bypassing the circumflex artery.
Findings:
- The patient successfully underwent beating coronary artery bypass grafting despite his extremely low LVEF.
- Post-operative assessment revealed a significant improvement in LVEF to 51.6%.
Implications:
- This case demonstrates the potential for beating CABG in patients with previously prohibitive LVEF.
- The findings suggest that OPCAB or beating CABG, with appropriate support, can expand treatment options for patients with severe left ventricular dysfunction.
Abstract:
Beating coronary artery bypass grafting could be performed for a 47-year-old man with left ventricular ejection fraction (LVEF) of 9.3%. Post-operative LVEF was improved to 51.6%. Conventional coronary artery bypass grafting (CABG) used to be contraindicative for patients with LVEF below 20%. Recently, such patients are involved to indication of off-pump CABG (OPCAB) or beating CABG, because we consider OPCAB are lower complications than conventional CABG. We were able to bypass the circumflex for the patient while we had been used percutaneous cardio-pulmonary support (PCPS). We could perform beating coronary artery bypass grafting for a patient of the low LVEF.
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