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Single photon emission computerized tomography in children with developmental language disorder--a preliminary report
Bi-Fang Lee1, Pinchen Yang, Yuh-Jyh Jong
1Department of Nuclear Medicine, National Cheng Kung University Hospital, Tainan.
The Kaohsiung Journal of Medical Sciences
|December 13, 2002
Summary
Developmental language disorder (DLD) in children may stem from neurobiological issues. SPECT scans revealed significant cerebral blood flow discrepancies in the temporal lobes of most children with DLD.
Area of Science:
- Neuroscience
- Developmental Pediatrics
- Radiology
Background:
- Developmental Language Disorder (DLD) affects children's language acquisition despite normal cognitive and sensory function.
- Understanding the neurobiological underpinnings of DLD is crucial for early diagnosis and intervention.
Purpose of the Study:
- To investigate regional cerebral blood flow (rCBF) in children diagnosed with DLD.
- To identify potential neurobiological markers associated with DLD using SPECT imaging.
Main Methods:
- High-resolution single photon emission computerized tomography (SPECT) using 99mTc-HMPAO.
- Assessed rCBF in 11 children with DLD (mean age 5y 10m, mean nonverbal IQ 107).
- Defined inter-hemispheric flow discrepancy as >10% bilateral rCBF difference.
Main Results:
- 90.9% of children with DLD exhibited inter-hemispheric rCBF discrepancies.
- Temporal lobes were implicated in all affected children (lateral, medial, and mesial regions).
- Significant bilateral blood flow differences were observed in language-associated brain areas.
Conclusions:
- Preliminary findings suggest DLD may be linked to neurobiological abnormalities.
- Discrepant rCBF in temporal lobes may represent a potential biomarker for DLD.
- Further research is warranted to confirm these preliminary results in larger cohorts.