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[Enterotoxigenic Bacteroides fragilis as a factor in diarrhea]

Bengül Durmaz1

  • 1Inönü Universitesi Tip Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Malatya.

Mikrobiyoloji Bulteni
|December 13, 2002
PubMed

Insights

Enterotoxigenic Bacteroides fragilis (ETBF) causes diarrheal diseases in children and adults. This review covers ETBF

Area of Science:

  • Microbiology
  • Gastroenterology
  • Molecular Biology

Context:

  • Diarrheal diseases remain a significant global health concern with unclear etiologies for many cases.
  • Enterotoxigenic Bacteroides fragilis (ETBF) is implicated in diarrheal illnesses in children and adults.
  • B. fragilis toxin (BFT) plays a role in intestinal pathophysiology.

Purpose:

  • To review the molecular pathogenesis of ETBF.
  • To summarize the epidemiology of ETBF infections.
  • To discuss laboratory diagnostic methods for ETBF.

Summary:

  • ETBF strains produce B. fragilis toxin (BFT), which stimulates intestinal secretion and causes cytotoxicity.
  • BFT's role in inflammatory bowel disease and colon cancer is suggested through nuclear activation and oncogene expression.
  • This review consolidates current knowledge on ETBF as a diarrheal pathogen.

Impact:

  • Highlights the importance of ETBF in diarrheal disease etiology.
  • Provides insights into the potential link between ETBF and chronic gastrointestinal conditions.
  • Aids in understanding and diagnosing ETBF infections.

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