[The effect of hydrocortisone on DNA synthesis by sebaceous gland epithelial cells]

The autoradiography method demonstrated a single injection of hydrocortisone (10 mg per 100 g of body weight) to result in suppression of the cell transition from the G1 phase of the mitotic cycle to the S phase and in prolongation of the S phase of the epithelium of the acinar portion (sebocytes) and stratified epithelium of the excretory ducts of the sebaceous gland of rats. Later, after a decrease of the proliferative processes by hydrocortisone there occurred their increase which was higher than control. Hydrocortisone induced a more pronounced effect on the proliferative activity of the stratified epithelium of the excretory ducts than on the sebocytes of the acini.