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Spherical crystallization of celecoxib
A R Paradkar1, A P Pawar, J K Chordiya
1Department of Pharmaceutics, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Erandwane, Pune 411 038, Maharashtra, India. arparadkar@rediffmail.com
Drug Development and Industrial Pharmacy
|December 13, 2002
Summary
Spherical crystallization improved celecoxib
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Celecoxib demonstrates poor flow and compressibility, hindering pharmaceutical formulation.
- Spherical crystallization offers a potential solution for improving drug properties.
Purpose of the Study:
- To enhance the flow and compressibility of celecoxib through spherical crystallization.
- To investigate the impact of process parameters on the characteristics of celecoxib agglomerates.
Main Methods:
- Spherical crystallization using a solvent change method with acetone, dichloromethane (DCM), and water.
- Hydroxypropylmethylcellulose (HPMC) incorporation for strength and sphericity.
- 3(2) factorial design and response surface methodology to study process variables and their effects.
Main Results:
- Particle size, bulk density, mean yield pressure (MYP), and drug release were significantly influenced by bridging liquid amount and agitation speed.
- The interaction between variables notably affected the MYP.
- Characterization confirmed the properties of the spherical agglomerates.
Conclusions:
- Spherical crystallization effectively improved celecoxib's physical properties.
- Process parameters, particularly bridging liquid and agitation, are critical for controlling agglomerate characteristics and performance.
- This method offers a viable approach for formulating poorly flowing drugs like celecoxib.