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Lung function abnormalities in children with type I diabetes.

R van Gent1, H J L Brackel, M de Vroede

  • 1Department of Paediatrics, Sint Joseph Hospital, Veldhoven, The Netherlands. k.vanderent@wkz.azu.nl

Respiratory Medicine
|December 13, 2002
PubMed
Summary

Children with type I diabetes show increased airway resistance, a lung function abnormality. This finding is crucial for understanding potential impacts on future treatments like intrabronchial insulin therapy.

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Area of Science:

  • Pediatric Endocrinology
  • Pulmonary Medicine
  • Diabetology

Background:

  • Type I diabetes can affect lung function in adults.
  • Intrabronchial insulin therapy is a developing treatment for diabetes.

Purpose of the Study:

  • To assess lung function in children with type I diabetes.
  • To identify potential airway obstruction or resistance issues.

Main Methods:

  • Twenty-seven children with type I diabetes underwent lung function tests.
  • Measurements included airway obstruction, lung volumes, airway resistance, and diffusion capacity.

Main Results:

  • Total airway resistance (Raw) was significantly higher in diabetic children compared to controls (P < 0.001).

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  • Other lung function parameters showed no significant differences.
  • No correlation was found between lung function and disease duration, age, or HbA1c levels.

    • Conclusions:

    • Children with type I diabetes exhibit increased airway resistance.
    • These lung function abnormalities may impact the efficacy of intrabronchial insulin treatments.