Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oocyte patterning: dynein and kinesin, inc.

Robert S Cohen1

  • 1Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, USA. rcohen@ku.edu

Current Biology : CB
|December 13, 2002
PubMed
Summary

Dynein and kinesin motor proteins are essential for directing cargo within Drosophila oocytes. Kinesin likely facilitates dynein-mediated transport to the anterior cortex, suggesting a coordinated mechanism for intracellular movement.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1.

Molecular oncology·2015
Same author

Rab11 is required for epithelial cell viability, terminal differentiation, and suppression of tumor-like growth in the Drosophila egg chamber.

PloS one·2011
Same author

Evidence for a transport-trap mode of Drosophila melanogaster gurken mRNA localization.

PloS one·2010
Same author

Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary.

Development (Cambridge, England)·2007
Same author

Microtubule motors: LSD2 trips the toggle.

Current biology : CB·2005
Same author

The positional, structural, and sequence requirements of the Drosophila TLS RNA localization element.

RNA (New York, N.Y.)·2005

Area of Science:

  • Cell Biology
  • Molecular Motors
  • Developmental Biology

Background:

  • Intracellular transport is crucial for cellular organization and function.
  • Dynein and kinesin are motor proteins that move cargo along microtubules.
  • The specific roles and coordination of these motors in asymmetric cellular transport remain under investigation.

Purpose of the Study:

  • To elucidate the roles of dynein and kinesin in cargo transport to the anterior cortex of the Drosophila oocyte.
  • To investigate the potential indirect mechanism of kinesin in mediating this transport.

Main Methods:

  • Utilized genetic and cell biological approaches in Drosophila oocytes.
  • Analyzed the localization and function of dynein and kinesin during oogenesis.

Main Results:

  • Both dynein and kinesin are demonstrated to be necessary for transport to the anterior cortex.
  • Microtubule orientation suggests kinesin plays an indirect role, potentially by regulating dynein activity or recycling.

Conclusions:

  • Dynein and kinesin function collaboratively in anteriorly directed cargo transport.
  • Kinesin's role appears to be regulatory, influencing dynein's transport capacity in the Drosophila oocyte.

Related Experiment Videos