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Jaw development: chinless wonders.

Anthony Graham1

  • 1MRC Center for Developmental Neurobiology, 4th Floor New Hunts House, Guys Campus, Kings College London, London SE1 1UL, UK.

Current Biology : CB
|December 13, 2002
PubMed
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Distal-less (Dlx) genes pattern the vertebrate pharyngeal arch axis. Dlx-5 and Dlx-6 gene mutations transform the lower jaw into an upper jaw, providing clear evidence for this role.

Area of Science:

  • Developmental biology
  • Genetics
  • Evolutionary biology

Background:

  • Pharyngeal arches form craniofacial structures in vertebrates.
  • Regional gene expression patterns developmental axes.
  • Distal-less (Dlx) genes are implicated in patterning pharyngeal arches.

Purpose of the Study:

  • To investigate the role of Dlx gene expression in patterning the proximodistal axis of pharyngeal arches.
  • To provide genetic evidence for Dlx gene function in craniofacial development.

Main Methods:

  • Analysis of Dlx-5; Dlx-6 double mutant organisms.
  • Comparative analysis of wild-type and mutant craniofacial structures.

Main Results:

  • Dlx-5 and Dlx-6 genes are crucial for patterning the proximodistal axis of pharyngeal arches.

Related Experiment Videos

  • Loss of Dlx-5; Dlx-6 function results in the transformation of the lower jaw to an upper jaw phenotype.

    • Conclusions:

    • Regionally restricted Dlx gene expression is essential for establishing the proximodistal identity of pharyngeal arches.
    • Dlx genes play a conserved role in vertebrate jaw development.