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Updated: Aug 12, 2026

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
Tumor-derived exosomes: a new source of tumor rejection antigens
F André1, N E C Schartz, N Chaput
1Unite d'immunologie, Immunology Unit, Institut Gustave Roussy, 39 rue Camille-Desmoulins, F-94805 Villejuif Cedex, France. uimmunoc@igr.fr
Abstract:
Exosomes are small vesicles released by a broad array of hematopoietic cells. Previous studies showed that exosomes released by antigen loaded dendritic cells induce immune-mediated anti-tumor response in mice. Here, we will describe the biochemical properties of tumor-derived exosomes and, their pre-clinical activity as cancer vaccines.
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