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Comparison of leuprolide acetate and triptorelin in assisted reproductive technology cycles: a prospective,
Raoul Orvieto1, Ram Kerner, Haim Krissi
1Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tiqva, Israel.
Objective:
To compare the use of two depot GnRH-a, leuprolide and triptorelin, in long-suppression GnRH-a protocols.
Design:
Prospective, randomized study.
Setting:
An IVF unit of an academic medical center.Fifty-two women who underwent controlled ovarian hyperstimulation and IVF.
Intervention(S):
Patients were prospectively randomized to receive 3.75 mg depot formulations of either leuprolide or triptorelin on days 21-23 of the menstrual cycle. Stimulation with gonadotropins was initiated after pituitary desensitization was achieved.
Main Outcome Measure(S):
The stimulation pattern and cycle outcomes were compared between the two groups.
Result(S):
Twenty-six patients were included in each group. No significant differences were observed in the patient age, estrogen, and P levels on day of hCG administration, gonadotropin dosage, number of oocytes retrieved, fertilization rate, percentage of high-quality embryos, and number of embryos transferred. However, significantly higher clinical implantation and pregnancy rates were found in the leuprolide group compared with the triptorelin group.
Conclusion(S):
A depot preparation of leuprolide is associated with higher implantation and pregnancy rates than a depot preparation of triptorelin when it is used in the midluteal phase as part of the long-suppression GnRH-a protocol in IVF.