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Related Experiment Videos

A self consistent normalized calibration protocol for three dimensional magnetic resonance gel dosimetry.

Richard L Cardenas1, Kwan Hon Cheng, Lynn J Verhey

  • 1Department of Physics, Texas Tech University, Lubbock, TX 79409-1051, USA.

Magnetic Resonance Imaging
|December 13, 2002
PubMed
Summary

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Accurate dose verification in radiation therapy requires on-site calibration for aqueous polymeric gels. An internal normalized calibration protocol significantly improves the accuracy of three-dimensional dosimeter dose distributions in clinical settings.

Area of Science:

  • Medical Physics
  • Radiotherapy
  • Polymer Science

Background:

  • Magnetic Resonance Relaxation imaging of irradiated aqueous polymeric gels shows inconsistent results for 3D dosimeter dose verification in conformal radiation therapy.
  • Calibration challenges at clinical sites, due to variations in gel sensitivity post-delivery, lead to inaccuracies.

Purpose of the Study:

  • To compare three dose calibration protocols for aqueous polymeric gels used as 3D dosimeters in a clinical setting.
  • To identify an accurate calibration method that accounts for variations in gel dosimeters under clinical conditions.

Main Methods:

  • Three calibration protocols were evaluated: off-site manufacturer calibration (Cal-1), on-site external tube gel calibration (Cal-2), and on-site internal normalized gel calibration (Cal-3).
  • Three-dimensional proton relaxation maps of irradiated gels were acquired and dose distributions were generated.

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  • Experimental dose distributions were compared against theoretical distributions from treatment-planning systems.

    • Main Results:

    • Cal-1 and Cal-2 protocols resulted in dose distribution inaccuracies of 10-40% and up to 200% above predicted maximum dose, respectively.
    • The on-site internal normalized calibration (Cal-3) achieved dose distributions within 10% of theoretical values.
    • Significant variations in dose sensitivity were observed due to clinical factors like oxygen contamination, temperature, and shelf life.

    Conclusions:

    • On-site internal normalized calibration is crucial for each batch of gel dosimeters at the time of MR imaging.
    • This protocol compensates for dose sensitivity variations in clinical settings, ensuring reliable 3D dosimeter accuracy.
    • Accurate dose verification using polymeric gel dosimeters necessitates independent, on-site calibration protocols.