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Hepatitis agents with enteric transmission--an epidemiological analysis
1Dept. of Clinical Microbiology and Infectious Diseases, S. Demirel University, Faculty of Medicine, Isparta, Turkey.
Background:
Viral hepatitis is characterized by special clinical, biochemical and serological findings. This study was planned to determine the seroprevalence, epidemiological characteristics and clinical and biochemical findings of hepatitis A virus (HAV) and hepatitis E virus (HEV) infections during an outbreak of jaundice.
Materials And Methods:
340 children aged 5-16 years were included. Clinical findings and alanine aminotransferase (ALT) levels were documented. Anti-HAV IgG and IgM in addition to anti-HEV IgG and IgM were determined by microELISA.
Results:
Clinical findings, high levels of ALT, anti-HAV IgM and IgG, anti-HEV IgM and IgG were present in 6%, 23%, 17%, 100%, 7% and 9% of cases, respectively. The relationship between ALT levels and anti-HAV or anti-HEV IgM seropositivity was significant (p
Conclusion:
HAV and HEV infection were both caused by a contaminated water supply.