Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Scale-up of polymerization processes.

Thierry Meyer1

  • 1Swiss Federal Institute of Technology, Institute of Chemical and Biological Process Science, 1015 Lausanne, Switzerland. thierry.meyer@epfl.ch

Current Opinion in Drug Discovery & Development
|December 14, 2002
PubMed
Summary

Integrating multidisciplinary approaches is key for successful chemical process scale-up. Balancing chemistry, EHS compliance, and economics ensures consistent product quality from lab to industrial scale.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developing safe and sustainable work activities in the industries of the future in metal additive manufacturing. A literature review of methods and proposals.

Applied ergonomics·2025
Same author

Autonomous communication with normative information facilitates positive spillover: promoting pro-environmental behaviors in a local setting.

The Journal of social psychology·2024
Same author

Electric personal mobility device driver behaviors, their antecedents and consequences: A narrative review.

Journal of safety research·2023
Same author

The need for awareness and action in managing nanowaste.

Nature nanotechnology·2023
Same author

Promoting a hand sanitizer by persuasive messages: moving bottle and background color as approach and avoidance cues.

Current psychology (New Brunswick, N.J.)·2022
Same author

Psychological Antecedents of the Intention to Open the Windows at Home and Exposure to a Ventilation Recommendation.

Frontiers in psychology·2022

Area of Science:

  • Chemical Engineering
  • Process Development

Background:

  • Scale-up and scale-down are critical for chemical process development.
  • These procedures require a multidisciplinary approach integrating science and engineering.

Purpose of the Study:

  • To highlight the importance of a balanced, multidisciplinary approach in chemical process scale-up.
  • To emphasize the need for accurate modeling and phenomenological understanding for successful scale-up.

Main Methods:

  • Integrating chemistry, design, environment, hygiene, and safety (EHS) factors.
  • Utilizing iterative process development with early concept discrimination.
  • Developing rational mathematical models based on phenomenological understanding and accurate parameter estimation.

Main Results:

  • Successful scale-up requires balancing multiple factors including EHS and economics.
  • Not all pilot scales are representative of industrial scaled-down sizes.
  • Accurate mathematical models are essential for predicting reactor behavior and product quality.

Conclusions:

  • Accomplished process development ensures consistent product properties across scales.
  • A holistic, multidisciplinary strategy is vital for effective chemical process scale-up.
  • Phenomenological understanding and accurate modeling are prerequisites for reliable scale-up.

Related Experiment Videos